Oprah Winfrey has no desire to make a bid to run for the U.S. presidency.

The TV host and actress gave an inspiring speech addressing sexism and racism at the Golden Globe Awards earlier this month, sparking speculation she would head up a campaign to oust U.S. President Donald Trump in 2020.

However, in an interview with InStyle magazine, the 63-year-old star ruled out running to become America's next leader, despite calls from fans to enter the race.

"It's not something that interests me," she said. "I don't have the DNA for it."

Oprah did admit she had spoken to her friend, TV newswoman Gayle King about a potential presidential campaign, but both agree that a political career is not for her.

"Gayle – who knows me as well as I know myself practically – has been calling me regularly and texting me things, like a woman in the airport saying, 'When's Oprah going to run?'" she explained. "So, Gayle sends me these things, and then she'll go, 'I know, I know, I know! It wouldn't be good for you – it would be good for everyone else.'"

Such was the clamor for Oprah to run that even President Trump has commented on the idea of her becoming a candidate.

"Oprah will be a lot of fun," Trump, 71, recently said, noting that he appeared on one of the final episodes of The Oprah Winfrey Show in 2011.

During her Golden Globes speech, Oprah made a veiled reference to Trump, who has called sexual misconduct allegations against him "fake news".

"I value the press more than ever before as we try to navigate these complicated times," she said. "Which brings me to this: what I know for sure, is that speaking your truth is the most powerful tool we all have, and I'm especially proud and inspired by all the women who have felt strong enough and empowered enough to speak up and share their personal stories."